The Raman flow bench is a key component of the Raman flow assembly system that brings Raman spectroscopy to downstream bioprocessing. This Raman flow assembly system meets the speed demands of downstream by optimizing Raman collection for low-turbidity, low volume samples. Ideally suited for development-scale flow rates, it provides real-time process monitoring, rapid optimization, and control for chromatography and other downstream unit operations.
Downstream: aggregation, protein crystallization, formula stability, product CQA, protein concentration, buffer excipients
Midstream: analyte monitoring in permeate
Ventajas
The Raman flow bench houses a Raman flow cell and easily connects to an Rxn-10 probe paired with a Raman Rxn embedded analyzer
Brings Raman-based process insights and control to downstream bioprocessing unit operations
Incorporates ambient light control as well as signal amplification
Tecnología de espectroscopia Raman, tecnología avanzada de análisis óptico
Mejore la seguridad de su planta, garantice la calidad de su producto y optimice sus operaciones. La espectroscopia Raman mide la composición y estructura molecular en tiempo real a partir de muestras tomadas en proceso con calidad de laboratorio.
Raman downstream process measurement of biosimilars - Alvotech’s testing of the protein purification process during ultrafiltration/diafiltration (UF/DF)
Endress+Hauser - your one-source Life Sciences technology partner
PU (publicación)
Versión en inglés - 06/2024
New version available in English
Graphic highlighting why Endress+Hauser is trusted by the world's top biopharmaceutical manufacturers for its Life Sciences expertise and reliable inline, real-time measurement technologies like Raman spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E).
Prioritize scalability for an efficient biopharmaceutical
product development lifecycle
PU (publicación)
Versión en checo - 09/2024
New version available in English
This technical paper studies the importance of scalability as a competitive advantage in bioprocessing in the Life Science industry, and Endress+Hauser's scalable Raman systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology and Liquid Analysis portfolio (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E).
Raman flow assembly - Precise composition measurement of
high-speed, low-volume samples in downstream bioprocessing
PU (publicación)
Versión en inglés - 05/2023
New version available in English
An overview of the Raman flow assembly (flow bench and flow cell) used with the Rxn-10 probe in conjunction with a Raman Rxn2 analyzer and a Raman flow assembly calibration and verification kit for downstream bioprocessing (powered by Kaiser Raman technology).
Raman calibration and verification kits - Everything needed to
calibrate and verify your Raman analyzer system for lab-to-process
scalability
PU (publicación)
Versión en inglés - 12/2023
New version available in English
An overview of the Raman calibration and verification kits for the bio multi optic / single use optic and the Raman flow assembly (includes the flow bench and flow cell). These kits are to be used in conjunction with the Rxn-10 probe and Raman Rxn2 / Rxn4 analyzer for upstream and downstream bioprocessing (powered by Kaiser Raman technology).
Prioritize scalability for an efficient biopharmaceutical
product development lifecycle
PU (publicación)
Versión en inglés - 06/2024
New version available in English
This technical paper studies the importance of scalability as a competitive advantage in bioprocessing in the Life Science industry, and Endress+Hauser's scalable Raman systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology and Liquid Analysis portfolio (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E).
Endress+Hauser - your one-source Life Sciences technology partner
PU (publicación)
Versión en checo - 09/2024
New version available in English
Graphic highlighting why Endress+Hauser is trusted by the world's top biopharmaceutical manufacturers for its Life Sciences expertise and reliable inline, real-time measurement technologies like Raman spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E).
Lab-to-process monitoring & control in Life Sciences -
Reliable measurement of bioprocess physical and
chemical properties
PU (publicación)
Versión en inglés - 04/2024
New version available in English
A combined product list of analysis offerings from both Optical Analysis and LIquid Analysis for bioprocessing applications in the life science industry (including Raman Rxn2 analyzer, Raman Rxn4 analyzer, Rxn-10 probe, bio multi optic and bio sleeve, Raman flow assembly, Rxn-45 probe, Rxn-46 probe, Raman optic system for single use, Memosens CPS61E, Memosens COS81E, OUSBT66, Memosens CPS61E, Memosens CPS77E, Memosens CLS82E, OUSAF44, Memosens CPS11E, Memosens CLS16E, TOC Analyzer CA79, Liquiline transmitter platform, and Memobase software).
Faster market entry, higher yields, and improved
quality - Real-time, inline bioprocess monitoring and
control from lab to GMP with Raman Rxn systems &
Memosens digital sensors
Folleto de competencia (CP)
Versión en inglés - 06/2024
New version available in English
This eBook highlights the Endress+Hauser inline analysis portfolio for bioprocessing including Raman spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E) in the Life Science industry.
Faster market entry, higher yields, and improved
quality - Real-time, inline bioprocess monitoring and
control from lab to GMP with Raman Rxn systems &
Memosens digital sensors
Folleto de competencia (CP)
Versión en checo - 09/2024
New version available in English
This eBook highlights the Endress+Hauser inline analysis portfolio for bioprocessing including Raman spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E) in the Life Science industry.
Raman downstream process measurement of biosimilars -
Alvotech's monitoring of the protein purification process
during ultrafiltration / diafiltration (UF/DF)
Estudio de caso (CS)
Versión en inglés - 06/2024
New version available in English
This case study examines Alvotech's use of Raman systems (Raman Rxn2 analyzer with Rxn-10 probe and Raman flow assembly) to monitor the downstream protein purification process during UF/DF.
Raman downstream process measurement of biosimilars -
Alvotech's monitoring of the protein purification process
during ultrafiltration / diafiltration (UF/DF)
Estudio de caso (CS)
Versión en checo - 09/2024
New version available in English
This case study examines Alvotech's use of Raman systems (Raman Rxn2 analyzer with Rxn-10 probe and Raman flow assembly) to monitor the downstream protein purification process during UF/DF.
Raman technology in bioprocessing - Scalable in situ bioprocess
monitoring enabling advanced process control
Innovación (IN)
Versión en inglés - 06/2023
New version available in English
An overview brochure about our Raman spectroscopy analyzer and probe portfolio, powered by Kaiser Raman technology, for the bioprocessing / biopharmaceutical industry (including the Raman Rxn2 analyzer, Raman Rxn4 analyzer, Rxn-10 probe, Rxn-45 probe, Rxn-46 probe, and probe accessory optics (bIO-Optic, Raman single use optic system, bio multi optic with bio sleeve, and Raman flow assembly), powered by Kaiser Raman technology.
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